furan-2-carboxylic acid [5-((S)-1-phenyl-ethylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide

Base Information

• Chemical Name: furan-2-carboxylic acid [5-((S)-1-phenyl-ethylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide
• CAS No.: 1419866-23-1
• Molecular Formula: C₃₁H₃₂N₄O₃
• Molecular Weight: 508.62
• Mol file: 1419866-23-1.mol

Synonyms:furan-2-carboxylic acid [5-((S)-1-phenyl-ethylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide

Chemical Property of furan-2-carboxylic acid [5-((S)-1-phenyl-ethylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of furan-2-carboxylic acid [5-((S)-1-phenyl-ethylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide

There total 5 articles about furan-2-carboxylic acid [5-((S)-1-phenyl-ethylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

(S)-1-phenyl-ethylamine (2627-86-3) + 3-[(furan-2-carbonyl)-amino]-4-(4-o-tolyl-piperazin-1-yl)-benzoic acid (1419871-57-0) → furan-2-carboxylic acid [5-((S)-1-phenyl-ethylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide (1419866-23-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

3-nitro-4-(4-o-tolyl-piperazin-1-yl)-benzoic acid (1053683-02-5) → furan-2-carboxylic acid [5-((S)-1-phenyl-ethylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide (1419866-23-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; 5%-palladium/activated carbon / ethanol; methanol / 4 h / Inert atmosphere

2: triethylamine / dichloromethane / 6 h / 0 - 25 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

With 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; dichloromethane;

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → furan-2-carboxylic acid [5-((S)-1-phenyl-ethylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide (1419866-23-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: hydrogen; 5%-palladium/activated carbon / ethanol; methanol / 4 h / Inert atmosphere

3: triethylamine / dichloromethane / 6 h / 0 - 25 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

With 5%-palladium/activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(S)-1-phenyl-ethylamine

3-[(furan-2-carbonyl)-amino]-4-(4-o-tolyl-piperazin-1-yl)-benzoic acid

3-nitro-4-(4-o-tolyl-piperazin-1-yl)-benzoic acid

3-nitro-4-fluorobenzoic acid