ethyl (2E,4S)-6-(1,3-dihydro-3-hydroxy-1-oxoisoindol-2-yl)-4-(tert-butyldiphenylsilyl)oxyhex-2-enoate

Base Information

Chemical Name:ethyl (2E,4S)-6-(1,3-dihydro-3-hydroxy-1-oxoisoindol-2-yl)-4-(tert-butyldiphenylsilyl)oxyhex-2-enoate
CAS No.:287728-34-1
Molecular Formula:C₃₂H₃₇NO₅Si
Molecular Weight:543.735
Hs Code.:

Synonyms:ethyl (2E,4S)-6-(1,3-dihydro-3-hydroxy-1-oxoisoindol-2-yl)-4-(tert-butyldiphenylsilyl)oxyhex-2-enoate

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Chemical Property of ethyl (2E,4S)-6-(1,3-dihydro-3-hydroxy-1-oxoisoindol-2-yl)-4-(tert-butyldiphenylsilyl)oxyhex-2-enoate

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Technology Process of ethyl (2E,4S)-6-(1,3-dihydro-3-hydroxy-1-oxoisoindol-2-yl)-4-(tert-butyldiphenylsilyl)oxyhex-2-enoate

There total 8 articles about ethyl (2E,4S)-6-(1,3-dihydro-3-hydroxy-1-oxoisoindol-2-yl)-4-(tert-butyldiphenylsilyl)oxyhex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 287728-24-9
ethyl (2E,4S)-4-(tert-butyldiphenylsilyl)oxy-6-phthalimidohex-2-enoate

: 287728-34-1
ethyl (2E,4S)-6-(1,3-dihydro-3-hydroxy-1-oxoisoindol-2-yl)-4-(tert-butyldiphenylsilyl)oxyhex-2-enoate

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at -40 ℃;
DOI:10.1016/S0040-4039(00)00485-8

Reference yield:

: 287728-31-8
(S)-4-phthalimido-1,2-butanediol

: 287728-34-1
ethyl (2E,4S)-6-(1,3-dihydro-3-hydroxy-1-oxoisoindol-2-yl)-4-(tert-butyldiphenylsilyl)oxyhex-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / imidazole / CH₂Cl₂ / 0 - 20 °C

2.1: imidazole / CH₂Cl₂; dimethylformamide / 20 °C

2.2: 89 percent / aq. HF / acetonitrile / 20 °C

3.1: DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / -78 - 0 °C

4.1: 5.78 g / CH₂Cl₂ / 20 °C

5.1: 92 percent / NaBH₄ / methanol; tetrahydrofuran / -20 °C

With 1H-imidazole; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1039/b303031h

Reference yield:

: 287728-30-7
(S)-2,2-dimethyl-4-(2-phthalimidoethyl)-1,3-dioxolane

: 287728-34-1
ethyl (2E,4S)-6-(1,3-dihydro-3-hydroxy-1-oxoisoindol-2-yl)-4-(tert-butyldiphenylsilyl)oxyhex-2-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / aq. HCl / tetrahydrofuran / 0.5 h / 60 °C

2.1: 97 percent / imidazole / CH₂Cl₂ / 0 - 20 °C

3.1: imidazole / CH₂Cl₂; dimethylformamide / 20 °C

3.2: 89 percent / aq. HF / acetonitrile / 20 °C

4.1: DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / -78 - 0 °C

5.1: 5.78 g / CH₂Cl₂ / 20 °C

6.1: 92 percent / NaBH₄ / methanol; tetrahydrofuran / -20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Swern oxidation;
DOI:10.1039/b303031h