ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

Base Information

Chemical Name:ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate
CAS No.:771584-91-9
Molecular Formula:C₂₆H₃₅N₅O₄S
Molecular Weight:513.661
Hs Code.:

Synonyms:ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

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Chemical Property of ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

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Technology Process of ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

There total 6 articles about ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 771584-88-4
ethyl ({[(2E)-3-(3-cyanophenyl)prop-2-en-1-yl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

: 771584-91-9
ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

Guidance literature:: ethyl ({[(2E)-3-(3-cyanophenyl)prop-2-en-1-yl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate; With hydrogenchloride; In ethanol; chloroform; at -20 - 5 ℃; for 21h;

With ammonium acetate; In 1,4-dioxane; ethanol; at 20 ℃; for 19h;

With hydrogenchloride;
DOI:10.1016/j.bmc.2004.07.046

Reference yield:

: 4318-37-0
1-Methylhomopiperazine

: 771584-91-9
ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 69 percent / K₂CO₃ / dimethylformamide / 17 h / 100 °C

2.1: H₂ / Pd/C / ethanol / 2 h / 20 °C

3.1: 35 percent / AcOH; NaB(OAc)3H / CH₂Cl₂ / 2 h / 20 °C

4.1: 44 percent / pyridine / 1,2-dichloro-ethane / 17 h / 20 °C

5.1: HCl / ethanol; CHCl₃ / 21 h / -20 - 5 °C

5.2: NH₄OAc / ethanol; dioxane / 19 h / 20 °C

5.3: 23 percent / aq. HCl

With pyridine; hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 5.1: Pinner reaction;
DOI:10.1016/j.bmc.2004.07.046

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 771584-91-9
ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 69 percent / K₂CO₃ / dimethylformamide / 17 h / 100 °C

2.1: H₂ / Pd/C / ethanol / 2 h / 20 °C

3.1: 35 percent / AcOH; NaB(OAc)3H / CH₂Cl₂ / 2 h / 20 °C

4.1: 44 percent / pyridine / 1,2-dichloro-ethane / 17 h / 20 °C

5.1: HCl / ethanol; CHCl₃ / 21 h / -20 - 5 °C

5.2: NH₄OAc / ethanol; dioxane / 19 h / 20 °C

5.3: 23 percent / aq. HCl

With pyridine; hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 5.1: Pinner reaction;
DOI:10.1016/j.bmc.2004.07.046