(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-allyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-allyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester
CAS No.:189178-50-5
Molecular Formula:C₂₀H₂₁F₃O₆
Molecular Weight:414.378
Hs Code.:

Synonyms:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-allyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-allyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester

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Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-allyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester

There total 2 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-allyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: (S)-5-Allyl-5-hydroxymethyl-3,3-dimethyl-furan-2,4-dione

: 189178-50-5
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-allyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/jo970106l

Reference yield:

: 189178-48-1
3-[(2R,4S)-4-Allyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolan-4-yl]-2,2-dimethyl-3-oxo-propionic acid ethyl ester

: 189178-50-5
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-allyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / p-TsOH / methanol / 0.5 h / Ambient temperature

2: 89 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo970106l

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 189178-50-5
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-allyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester

: (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methoxycarbonylmethyl-4,4-dimethyl-3,5-dioxo-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With ruthenium trichloride; sodium periodate; Yield given. Multistep reaction; 1.) CCl₄, CH₃CN, H₂O, room temperature, 4 h, 2.) ether, room temperature, 5 min.;
DOI:10.1021/jo970106l