2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile

Base Information

Chemical Name:2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile
CAS No.:84353-41-3
Molecular Formula:C₁₉H₁₄ClN₃O
Molecular Weight:335.793
Hs Code.:

Synonyms:2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile

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Chemical Property of 2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile

Chemical Property:

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Technology Process of 2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile

There total 4 articles about 2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 38072-61-6
2-(4-Chlorphenyl)-methyliden-1-methylindolin-3-on

: 109-77-3
malononitrile

: 84353-41-3
2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile

Guidance literature:: With piperidine; In ethanol; for 0.5h;

Reference yield: 70.0%

: 38072-62-7
2-(4-Chlorphenyl)-methyliden-1-methylindolin-3-on

: 109-77-3
malononitrile

: 84353-41-3
2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile

Guidance literature:: With piperidine; In ethanol; for 0.5h;

Reference yield:

: 3260-63-7
1-methyl-1H-indol-3-yl acetate

: 84353-41-3
2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / 1.5 M NaOH / ethanol / 2 h / Heating

2: 70 percent / piperidine / ethanol / 0.5 h

With piperidine; sodium hydroxide; In ethanol;