2-allylcyclohex-1-enecarboxylic acid 1-(2-allyloxyethyl)-3-(4-methoxybenzyloxy)propyl ester

Base Information

• Chemical Name: 2-allylcyclohex-1-enecarboxylic acid 1-(2-allyloxyethyl)-3-(4-methoxybenzyloxy)propyl ester
• CAS No.: 794588-65-1
• Molecular Formula: C₂₆H₃₆O₅
• Molecular Weight: 428.569
• Mol file: 794588-65-1.mol

Synonyms:2-allylcyclohex-1-enecarboxylic acid 1-(2-allyloxyethyl)-3-(4-methoxybenzyloxy)propyl ester

Chemical Property of 2-allylcyclohex-1-enecarboxylic acid 1-(2-allyloxyethyl)-3-(4-methoxybenzyloxy)propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-allylcyclohex-1-enecarboxylic acid 1-(2-allyloxyethyl)-3-(4-methoxybenzyloxy)propyl ester

There total 2 articles about 2-allylcyclohex-1-enecarboxylic acid 1-(2-allyloxyethyl)-3-(4-methoxybenzyloxy)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-allyl-1-cyclohexenecarboxylic acid + 1-allyloxy-5-(4-methoxybenzyloxy)pentan-3-ol (794588-45-7) → 2-allylcyclohex-1-enecarboxylic acid 1-(2-allyloxyethyl)-3-(4-methoxybenzyloxy)propyl ester (794588-65-1)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In diethyl ether; at 0 - 20 ℃;

DOI:10.1016/j.tet.2004.06.146

Reference yield:

(S)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)pentan-1-ol (794588-83-3) → 2-allylcyclohex-1-enecarboxylic acid 1-(2-allyloxyethyl)-3-(4-methoxybenzyloxy)propyl ester (794588-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / NaH / tetrahydrofuran / 20 h / 20 °C

2: 74 percent / TBAF / tetrahydrofuran / 5 h / 20 °C

3: 84 percent / diisopropyl azodicarboxylate; PPh₃ / diethyl ether / 0 - 20 °C

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; 3: Mitsunobu reaction;

DOI:10.1016/j.tet.2004.06.146

upstream raw materials:

1-allyloxy-5-(4-methoxybenzyloxy)pentan-3-ol

(S)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)pentan-1-ol