4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide

Base Information

Chemical Name:4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide
CAS No.:1432731-27-5
Molecular Formula:C₂₁H₁₅FN₄O₂
Molecular Weight:374.374
Hs Code.:

Synonyms:4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide

Suppliers and Price of 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide

There total 8 articles about 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.7%

: 1432731-26-4
4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carbonitrile

: 1432731-27-5
4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide

Guidance literature:: With sodium percarbonate; In water; acetone; at 50 ℃; for 2h;

Reference yield:

: 1044278-42-3
4-chloro-7-methylquinoline-2-carbonitrile

: 1432731-27-5
4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 16 h / 100 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 180 °C / Microwave irradiation

4: sodium percarbonate / water; acetone / 2 h / 50 °C

With sodium percarbonate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; tetrachloromethane; water; acetone; acetonitrile; 1: |Suzuki Coupling;

Reference yield:

: 932369-61-4
4-(4-fluorophenyl)-7-methylquinoline-2-carbonitrile

: 1432731-27-5
4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 180 °C / Microwave irradiation

3: sodium percarbonate / water; acetone / 2 h / 50 °C

With sodium percarbonate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); N-ethyl-N,N-diisopropylamine; In tetrachloromethane; water; acetone; acetonitrile;