2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide

Base Information

• Chemical Name: 2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide
• CAS No.: 220392-08-5
• Molecular Formula: C₂₄H₃₁N₃O₂S
• Molecular Weight: 425.595
• Mol file: 220392-08-5.mol

Synonyms:2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide

Chemical Property of 2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide

There total 5 articles about 2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-1-(1-phenyl-ethyl)piperidinium bromide → naratriptan (121679-13-8) + 2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide (220392-08-5)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at 60 ℃; for 22h; Title compound not separated from byproducts;

DOI:10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9

Reference yield:

(1-bromoethyl)benzne (585-71-7,38661-81-3) → 2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide (220392-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / acetone / 260 h / 50 °C

2: lithium tri-sec-butylborohydride / tetrahydrofuran / 22 h / 60 °C

With L-Selectride; In tetrahydrofuran; acetone; 1: quaternisation / 2: dequaternisation;

DOI:10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9

Reference yield:

naratriptan (121679-13-8) → 2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide (220392-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / acetone / 260 h / 50 °C

2: lithium tri-sec-butylborohydride / tetrahydrofuran / 22 h / 60 °C

With L-Selectride; In tetrahydrofuran; acetone; 1: quaternisation / 2: dequaternisation;

DOI:10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9

upstream raw materials:

(1-bromoethyl)benzne

naratriptan