8-AZAGUANINE

Base Information

• Chemical Name: 8-AZAGUANINE
• CAS No.: 134-58-7
• Molecular Formula: C4H4N6O
• Molecular Weight: 152.115
• Hs Code.: 2933.59
• Mol file: 134-58-7.mol

Synonyms:7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-1,4-dihydro- (9CI);7H-v-Triazolo[4,5-d]pyrimidin-7-one, 5-amino-1,6-dihydro-(8CI);v-Triazolo[4,5-d]pyrimidin-7-ol, 5-amino- (7CI);5-Amino-1H-v-triazolo[d]pyrimidin-7-ol;5-Amino-1H-vic-triazolo[d]pyrimidin-7-ol;5-Amino-7-hydroxy-1H-v-triazolo[d]pyrimidine;8-AG;Azaguanine;Azan;Guanazol;Guanazolo;NSC 151069;NSC 749;Pathocidin;Pathocidine;

Chemical Property of 8-AZAGUANINE

Chemical Property:

• Appearance/Colour: yellow powder
• Vapor Pressure: 0.00149mmHg at 25°C
• Melting Point: >300 °C(lit.)
• Refractive Index: 2.307
• Boiling Point: 289.9 °C at 760 mmHg
• PKA: 6.75±0.20(Predicted)
• Flash Point: 129.1 °C
• PSA: 113.34000
• Density: 2.64 g/cm³
• LogP: -0.79540
• Storage Temp.: −20°C
• Water Solubility.: 1.47E+004 mg/L

Purity/Quality:

99%, ^*data from raw suppliers

8-Azaguanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Antineoplastic;Purine antimetabolite 8-Azaguanine, is a purine analogue which shows antineoplastic activity.

Technology Process of 8-AZAGUANINE

There total 6 articles about 8-AZAGUANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 8-azaguanine (134-58-7)

Guidance literature:

DOI:10.7164/antibiotics.31.628

Reference yield:

dicyandiamide (127099-85-8,780722-26-1) + hydrazine hydrate (7803-57-8,79785-97-0) → 8-azaguanine (134-58-7)

Guidance literature:

byproducts: NH3; heating on water bath;

Reference yield:

hydrazine hydrochloride (2644-70-4,14011-37-1,5341-61-7) + dicyandiamide (127099-85-8,780722-26-1) → 8-azaguanine (134-58-7)

Guidance literature:

In ethanol; heating at 90°C;

upstream raw materials:

2,5,6-triamino-3,4-dihydro-4-pyrimidinone

dicyandiamide

hydrazine hydrate

hydrazine hydrochloride

Downstream raw materials:

[(2R,3R,4R,5R)-5-(5-amino-7-oxo-6H-triazolo[4,5-d]pyrimidin-3-yl)-3,4-dibenzoyloxy-tetrahydrofuran-2-yl]methyl benzoate

2-<(5-amino-6,7-dihydro-7-oxo-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)methoxy>ethyl benzoate

5-amino-3-(β-D-ribofuranosyl)-1,2,3-triazolo[4,5-d]pyrimidin-7-one 5'-monophosphate

8-azaguanosine

Refernces

• 1、 Trattner et al.. "-". . p. 2674. Retrieved 1964.