bisnortilidine

Base Information

• Chemical Name: bisnortilidine
• CAS No.: 53948-51-9
• Molecular Formula: C₁₅H₁₉NO₂
• Molecular Weight: 245.321
• Mol file: 53948-51-9.mol

Synonyms:3-Cyclohexene-1-carboxylicacid, 2-amino-1-phenyl-, ethyl ester, trans-(?à)-; 3-Cyclohexene-1-carboxylic acid,2-amino-1-phenyl-, ethyl ester, trans-; Bisnortilidine

Chemical Property of bisnortilidine

Chemical Property:

• Vapor Pressure: 9.32E-05mmHg at 25°C
• Boiling Point: 339.2°Cat760mmHg
• Flash Point: 186.8°C
• PSA: 52.32000
• Density: 1.094g/cm³
• LogP: 2.86510
• Storage Temp.: -20°C Freezer

Purity/Quality:

98%Min ^*data from raw suppliers

Bisnortilidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Tilidine (T440300)

Technology Process of bisnortilidine

There total 2 articles about bisnortilidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S)-1-Phenyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-cyclohex-3-enecarboxylic acid ethyl ester (1246819-95-3) → bisnortilidine (53948-51-9,67008-96-2,67010-15-5,71656-78-5)

Guidance literature:

With zinc; In acetic acid;

DOI:10.1021/jo01337a036

Reference yield:

→ bisnortilidine (53948-51-9,67008-96-2,67010-15-5,71656-78-5)

Guidance literature:

In acetic acid;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + bisnortilidine (53948-51-9,67008-96-2,67010-15-5,71656-78-5) → Tilidine (17243-69-5,20380-56-7,20380-58-9,32447-90-8,38690-93-6,51931-66-9,112244-09-4)

Guidance literature:

With sodium cyanoborohydride; In acetonitrile;

DOI:10.1021/jo01337a036

upstream raw materials:

(1R,2S)-1-Phenyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-cyclohex-3-enecarboxylic acid ethyl ester

Downstream raw materials:

Tilidine