1,3,3-trimethyl-5'-(3,4,5-trifluorophenyl)spiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine]

Base Information

Chemical Name:1,3,3-trimethyl-5'-(3,4,5-trifluorophenyl)spiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine]
CAS No.:1365120-01-9
Molecular Formula:C₂₈H₂₁F₃N₂O
Molecular Weight:458.483
Hs Code.:

Synonyms:1,3,3-trimethyl-5'-(3,4,5-trifluorophenyl)spiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine]

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Chemical Property of 1,3,3-trimethyl-5'-(3,4,5-trifluorophenyl)spiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine]

Chemical Property:

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Technology Process of 1,3,3-trimethyl-5'-(3,4,5-trifluorophenyl)spiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine]

There total 4 articles about 1,3,3-trimethyl-5'-(3,4,5-trifluorophenyl)spiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118-12-7
1,3,3-Trimethyl-2-methyleneindoline

: C₁₆H₈F₃NO₂

: 1365120-01-9
1,3,3-trimethyl-5'-(3,4,5-trifluorophenyl)spiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine]

Guidance literature:: In ethanol; at 100 ℃; for 3h;
DOI:10.1016/j.tetlet.2012.02.082

Reference yield:

: 524-42-5
1,2-naphthoquinone

: 1365120-01-9
1,3,3-trimethyl-5'-(3,4,5-trifluorophenyl)spiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine]

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium peroxydisulfate; silver nitrate / water; 1,2-dichloro-ethane / 5 h

2: hydroxylamine hydrochloride / ethanol / 18 h / 20 °C

3: ethanol / 3 h / 100 °C

With ammonium peroxydisulfate; hydroxylamine hydrochloride; silver nitrate; In ethanol; water; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2012.02.082

Reference yield:

: 143418-49-9
3,4,5-trifluorophenylboronic acid

: 1365120-01-9
1,3,3-trimethyl-5'-(3,4,5-trifluorophenyl)spiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine]

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium peroxydisulfate; silver nitrate / water; 1,2-dichloro-ethane / 5 h

2: hydroxylamine hydrochloride / ethanol / 18 h / 20 °C

3: ethanol / 3 h / 100 °C

With ammonium peroxydisulfate; hydroxylamine hydrochloride; silver nitrate; In ethanol; water; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2012.02.082