tert-butyl 3-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate

Base Information

• Chemical Name: tert-butyl 3-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate
• CAS No.: 256477-25-5
• Molecular Formula: C₂₀H₁₈Cl₂N₂O₄S
• Molecular Weight: 453.346
• Mol file: 256477-25-5.mol

Synonyms:tert-butyl 3-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate

Chemical Property of tert-butyl 3-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate

There total 8 articles about tert-butyl 3-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-benzoic acid t-butyl ester (58656-99-8) → tert-butyl 3-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate (256477-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 4.0 g / H₂ / Pd/C / ethanol / 4 h / 23 °C / 3102.97 Torr

2: NEt₃ / CH₂Cl₂ / 96 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm061066t

Reference yield:

tert-butyl 2-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate (256477-24-4) + n-butyllithium (109-72-8,29786-93-4) + 1,4,7-trichloroisoquinoline + hexanes-EtOAc + tert-butyl 3-aminobenzoate (92146-82-2) + 7-bromo-1,4-dichloroisoquinoline (223671-13-4) → tert-butyl 3-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate (256477-25-5)

Guidance literature:

With SO₂Cl₂; triethylamine; In THF-Et₂O; hexane; dichloromethane;

Reference yield:

3-nitrobenzoic acid (121-92-6) → tert-butyl 3-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate (256477-25-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.4 g / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 23 °C

2: 4.0 g / H₂ / Pd/C / ethanol / 4 h / 23 °C / 3102.97 Torr

3: NEt₃ / CH₂Cl₂ / 96 h / 20 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm061066t

upstream raw materials:

1,4-dichloro-7-isoquinolinesulphonyl chloride

tert-butyl 3-aminobenzoate

4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride

4-chloro-1-(2H)-isoquinolone

Downstream raw materials:

tert-butyl 3-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate

tert-butyl 3-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate