(R)-4-(3-chlorophenyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine-2,2-dioxide

Base Information

• Chemical Name: (R)-4-(3-chlorophenyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine-2,2-dioxide
• CAS No.: 1418635-75-2
• Molecular Formula: C₁₃H₁₀ClNO₃S
• Molecular Weight: 295.746
• Mol file: 1418635-75-2.mol

Synonyms:(R)-4-(3-chlorophenyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine-2,2-dioxide

Chemical Property of (R)-4-(3-chlorophenyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine-2,2-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-(3-chlorophenyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine-2,2-dioxide

There total 3 articles about (R)-4-(3-chlorophenyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine-2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-chlorophenylboronic acid (63503-60-6) + benzo[e][1,2,3]oxathiazine 2,2-dioxide (71730-46-6) → (R)-4-(3-chlorophenyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine-2,2-dioxide (1418635-75-2)

Guidance literature:

3-chlorophenylboronic acid; benzo[e][1,2,3]oxathiazine 2,2-dioxide; With chlorobis(cyclooctene)rhodium(I) dimer; C₁₈H₂₃NOS; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;

With potassium fluoride; In water; toluene; at 20 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja3110818

Reference yield: 98.0%

C12H10BClO2 (1025496-32-5) + benzo[e][1,2,3]oxathiazine 2,2-dioxide (71730-46-6) → (R)-4-(3-chlorophenyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine-2,2-dioxide (1418635-75-2)

Guidance literature:

With C₁₈H₂₃NOS; dichlorotetrakis(cyclooctene)dirhodium; In toluene; at 20 ℃; for 0.5h; enantioselective reaction;

DOI:10.1055/s-0033-1338418

Reference yield: 91.0%

→ (R)-4-(3-chlorophenyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine-2,2-dioxide (1418635-75-2)

Guidance literature:

With nickel(II) perchlorate hexahydrate; (4S,5S)-2-((R)-7′-(diphenylphosphanyl)-3,3,3′,3′,5,5′-hexamethyl-2,2′,3,3′-tetrahydro-1,1′-spirobi[inden]-7-yl)-4,5-diphenyl-4,5-dihydrooxazole; In 2,2,2-trifluoroethanol; at 60 ℃; for 48h; Schlenk technique; Inert atmosphere;

upstream raw materials:

3-chlorophenylboronic acid

benzo[e][1,2,3]oxathiazine 2,2-dioxide

C₁₂H₁₀BClO₂