4-((2,4-dimethoxybenzyI)amino)thieno[3,2-d]pyrimidine-7-carboxylic acid

Base Information

Chemical Name:4-((2,4-dimethoxybenzyI)amino)thieno[3,2-d]pyrimidine-7-carboxylic acid
CAS No.:1269667-39-1
Molecular Formula:C₁₆H₁₅N₃O₄S
Molecular Weight:345.379
Hs Code.:

Synonyms:4-((2,4-dimethoxybenzyI)amino)thieno[3,2-d]pyrimidine-7-carboxylic acid

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Chemical Property of 4-((2,4-dimethoxybenzyI)amino)thieno[3,2-d]pyrimidine-7-carboxylic acid

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Technology Process of 4-((2,4-dimethoxybenzyI)amino)thieno[3,2-d]pyrimidine-7-carboxylic acid

There total 9 articles about 4-((2,4-dimethoxybenzyI)amino)thieno[3,2-d]pyrimidine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1269667-40-4
methyl 4-((2,4-dimethoxybenzyl)amino)thieno[3,2-d]pyrimidine-7-carboxylate

: 1269667-39-1
4-((2,4-dimethoxybenzyI)amino)thieno[3,2-d]pyrimidine-7-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/acsmedchemlett.0c00344

Reference yield: 54.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1527518-20-2
7-bromo-N-(2,4-dimethoxybenzyl)thieno[3,2-d]pyrimidine-4-amine

: 1269667-39-1
4-((2,4-dimethoxybenzyI)amino)thieno[3,2-d]pyrimidine-7-carboxylic acid

Guidance literature:: 7-bromo-N-(2,4-dimethoxybenzyl)thieno[3,2-d]pyrimidine-4-amine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

carbon dioxide; In diethyl ether; hexane; at 20 ℃; for 2h; Cooling with ether-dry ice;

Reference yield:

: 16234-10-9
3H-thieno[3,2-d]pyrimidin-4-one

: 1269667-39-1
4-((2,4-dimethoxybenzyI)amino)thieno[3,2-d]pyrimidine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / acetic acid / 8 h / 100 °C

1.2: 20 °C

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 3 h / 120 °C / 15514.9 Torr / Autoclave

3.1: trichlorophosphate / 2 h / Reflux

3.2: Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 60 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

5.2: pH 3

With water; bromine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;