methyl 7-(3,4-difluorophenyl)-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate

Base Information

Chemical Name:methyl 7-(3,4-difluorophenyl)-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate
CAS No.:1160685-48-2
Molecular Formula:C₁₇H₁₂F₂N₂O₄
Molecular Weight:346.29
Hs Code.:

Synonyms:methyl 7-(3,4-difluorophenyl)-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate

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Chemical Property of methyl 7-(3,4-difluorophenyl)-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate

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Technology Process of methyl 7-(3,4-difluorophenyl)-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate

There total 6 articles about methyl 7-(3,4-difluorophenyl)-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.53%

: 1160683-61-3
methyl 7-bromo-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate

: 168267-41-2
(3,4-difluorophenyl)boronic acid

: 1160685-48-2
methyl 7-(3,4-difluorophenyl)-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 105 ℃;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160685-48-2
methyl 7-(3,4-difluorophenyl)-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr

5.2: 20 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 105 °C

With ammonium hydroxide; sulfuric acid; hydrogen; bromine; nitric acid; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160685-48-2
methyl 7-(3,4-difluorophenyl)-6-(methyloxy)-2-oxo-1,2-dihydro-5-quinoxalinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr

3.2: 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 105 °C

With hydrogen; bromine; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; water; ethyl acetate; mineral oil;