5'-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-2'-cyano-biphenyl-4-yl sulfamate

Base Information

Chemical Name:5'-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-2'-cyano-biphenyl-4-yl sulfamate
CAS No.:1260389-35-2
Molecular Formula:C₂₂H₁₇BrN₆O₃S
Molecular Weight:525.385
Hs Code.:

Synonyms:5'-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-2'-cyano-biphenyl-4-yl sulfamate

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Chemical Property of 5'-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-2'-cyano-biphenyl-4-yl sulfamate

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Technology Process of 5'-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-2'-cyano-biphenyl-4-yl sulfamate

There total 6 articles about 5'-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-2'-cyano-biphenyl-4-yl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1260389-54-5
5-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-4'-hydroxy-biphenyl-2-carbonitrile

: 1260389-35-2
5'-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-2'-cyano-biphenyl-4-yl sulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 6h;

Reference yield:

: 146631-00-7
[4-(benzyloxy)phenyl]boronic acid

: 1260389-35-2
5'-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-2'-cyano-biphenyl-4-yl sulfamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / Heating; Reflux

2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: hydrogenchloride; acetic acid / water / 1 h / 100 °C

4.2: 20 °C

5.1: sulphamoyl chloride / N,N-dimethyl acetamide / 6 h / 0 - 20 °C

With hydrogenchloride; sulphamoyl chloride; potassium tert-butylate; sodium hydride; sodium carbonate; acetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 36282-26-5
2-bromo-4-fluorobenzonitrile

: 1260389-35-2
5'-((4-bromo-benzyl)(4H-1,2,4-triazol-4-yl)amino)-2'-cyano-biphenyl-4-yl sulfamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / Heating; Reflux

2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: hydrogenchloride; acetic acid / water / 1 h / 100 °C

4.2: 20 °C

5.1: sulphamoyl chloride / N,N-dimethyl acetamide / 6 h / 0 - 20 °C

With hydrogenchloride; sulphamoyl chloride; potassium tert-butylate; sodium hydride; sodium carbonate; acetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;