ethyl 3-fluoro-3-phenylpropanoate

Base Information

• Chemical Name: ethyl 3-fluoro-3-phenylpropanoate
• CAS No.: 70199-99-4
• Molecular Formula: C₁₁H₁₃FO₂
• Molecular Weight: 196.221
• Mol file: 70199-99-4.mol

Synonyms:ethyl 3-fluoro-3-phenylpropanoate

Chemical Property of ethyl 3-fluoro-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-fluoro-3-phenylpropanoate

There total 8 articles about ethyl 3-fluoro-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl (2Z)-3-fluoro-3-phenylprop-2-enoate (105304-62-9) → ethyl 3-fluoro-3-phenylpropanoate (70199-99-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In toluene; for 1.5h; under 760.051 Torr; chemoselective reaction;

DOI:10.1016/j.jfluchem.2017.12.016

Reference yield: 81.0%

ethyl dihydrocinnamate (2021-28-5) → ethyl 3-fluoro-3-phenylpropanoate (70199-99-4)

Guidance literature:

With xanth-9-one; Selectfluor; In acetonitrile; at 60 ℃; for 0.466667h; Inert atmosphere; Flow reactor; Irradiation;

DOI:10.1021/jo5016757

Reference yield: 75.5%

Ethyl 3-hydroxy-3-phenylpropanoate (5764-85-2) → ethyl 3-fluoro-3-phenylpropanoate (70199-99-4)

Guidance literature:

With hexafluoropropene-diethylamine adduct; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0022-1139(00)81428-1

upstream raw materials:

phenylalanine ethyl ester

3-phenyl-3-<(trimethylsilyl)oxy>propanoate d'ethyle

Ethyl 3-hydroxy-3-phenylpropanoate

ethyl dihydrocinnamate