1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester
• CAS No.: 220239-29-2
• Molecular Formula: C₂₀H₂₀ClNO₅S
• Molecular Weight: 421.901
• Mol file: 220239-29-2.mol

Synonyms:1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester

Chemical Property of 1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester

Chemical Property:

Purity/Quality:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester

There total 1 articles about 1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.7%

(2E)-3-(2-thiophenyl)-2-propenoyl chloride (28424-61-5,73186-06-8,119924-24-2) + diethyl 2-[(4-chlorophenyl)amino]malonate (5203-01-0) → 1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester (220239-29-2)

Guidance literature:

With triethylamine; In benzene; for 6h; Heating;

DOI:10.1016/S0968-0896(98)80015-1

Reference yield: 99.0%

1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester (220239-29-2) → trans-1-(4-chlorophenyl)-4-(2-thienyl)-pyrrolidin-2-one-5-carboxylic acid

Guidance literature:

With potassium hydroxide; In ethanol; water; for 4h; Heating;

DOI:10.1016/S0968-0896(98)80015-1

Reference yield: 81.0%

1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester (220239-29-2) → 1-(4-chloro-phenyl)-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester

Guidance literature:

1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester; With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 25 - 30 ℃; for 2h;

In tetrahydrofuran; for 0.333333h; Heating;

DOI:10.1016/j.tetlet.2003.09.085

upstream raw materials:

(2E)-3-(2-thiophenyl)-2-propenoyl chloride

diethyl 2-[(4-chlorophenyl)amino]malonate