1-{4-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid methyl ester

Base Information

Chemical Name:1-{4-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid methyl ester
CAS No.:1215103-70-0
Molecular Formula:C₂₆H₂₇FN₄O₃
Molecular Weight:462.524
Hs Code.:

Synonyms:1-{4-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid methyl ester

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Chemical Property of 1-{4-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid methyl ester

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Technology Process of 1-{4-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid methyl ester

There total 1 articles about 1-{4-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[2-chloro-6-(4-fluorophenyl)-pyrimidin-4-yl]morpholine

: 1215017-84-7
methyl 1-(4-aminophenyl)cyclobutane-1-carboxylate

: 1215103-70-0
1-{4-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid methyl ester

Guidance literature:: In butan-1-ol; at 110 ℃; for 16h;

Reference yield: 86.0%

: 1215103-70-0
1-{4-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid methyl ester

: 1215102-84-3
1-{4-[4-(4-Fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid

Guidance literature:: 1-{4-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-cyclobutanecarboxylic acid methyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; Reflux;

In water; pH=4; Acidic conditions;