C₅₂H₇₆N₇O₁₆PS

Base Information

• Chemical Name: C₅₂H₇₆N₇O₁₆PS
• CAS No.: 1608113-86-5
• Molecular Formula: C₅₂H₇₆N₇O₁₆PS
• Molecular Weight: 1118.25
• Mol file: 1608113-86-5.mol

Synonyms:C₅₂H₇₆N₇O₁₆PS

Chemical Property of C₅₂H₇₆N₇O₁₆PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₂H₇₆N₇O₁₆PS

There total 14 articles about C₅₂H₇₆N₇O₁₆PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-For-L-Met-L-Lys(Boc)-L-Lys(Boc)-OH (1608114-09-5) + O,O-dibenzyl O-(5'-deoxythymidine-5'-yl)phosphate (5115-07-1) → C52H76N7O16PS (1608113-86-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201301781

Reference yield:

Dibenzyl N,N-diisopropylphosphoramidite (108549-23-1) → C52H76N7O16PS (1608113-86-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1H-tetrazole / dichloromethane; acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / -40 - 20 °C / Inert atmosphere

2.1: ammonia / methanol / 27 h / 0 - 20 °C / Inert atmosphere

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

With 1H-tetrazole; dmap; ammonia; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/ejoc.201301781

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → C52H76N7O16PS (1608113-86-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / water; dichloromethane / 4 h / 0 °C

3.1: 1H-tetrazole / dichloromethane; acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

3.2: 2 h / -40 - 20 °C / Inert atmosphere

4.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; 1H-tetrazole; dmap; triethylamine tris(hydrogen fluoride); dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/ejoc.201301781

upstream raw materials:

N-formyl-methionine-succinimidyl ester

thymidine

Dibenzyl N,N-diisopropylphosphoramidite

N-For-L-Met-L-Lys(Boc)-L-Lys(Boc)-OH