N-[4-[[3-(1,3)dioxolan-2-yl-phenyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

Base Information

• Chemical Name: N-[4-[[3-(1,3)dioxolan-2-yl-phenyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide
• CAS No.: 796863-74-6
• Molecular Formula: C₂₄H₃₂N₂O₅
• Molecular Weight: 428.528

Synonyms:N-[4-[[3-(1,3)dioxolan-2-yl-phenyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

Chemical Property of N-[4-[[3-(1,3)dioxolan-2-yl-phenyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

Chemical Property:

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Technology Process of N-[4-[[3-(1,3)dioxolan-2-yl-phenyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

There total 1 articles about N-[4-[[3-(1,3)dioxolan-2-yl-phenyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-(1,3-dioxolan-2-yl)benzaldehyde (68348-23-2) + 5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine (197229-98-4) → N-[4-[[3-(1,3)dioxolan-2-yl-phenyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide (796863-74-6)

Guidance literature:

5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 - 0 ℃;

3-(1,3-dioxolan-2-yl)benzaldehyde; In tetrahydrofuran; hexane; at -78 - 0 ℃;

DOI:10.1021/jm0407658

Reference yield: 73.0%

N-[4-[[3-(1,3)dioxolan-2-yl-phenyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide (796863-74-6) → N-[4-[[3-(1,3)dioxolan-2-ylbenzoyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide (796863-78-0)

Guidance literature:

With potassium permanganate; Tris(3,6-dioxaheptyl)amine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm0407658

Reference yield: 24.0%

N-[4-[[3-(1,3)dioxolan-2-yl-phenyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide (796863-74-6) → 3-[(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydropyridin)-4-ylmethyl]benzaldehyde (796863-75-7)

Guidance literature:

With hydrogenchloride; acetic acid; tin(ll) chloride; at 100 ℃;

DOI:10.1021/jm0407658

upstream raw materials:

3-(1,3-dioxolan-2-yl)benzaldehyde

5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine

Downstream raw materials:

3-[(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydropyridin)-4-ylmethyl]benzaldehyde

N-[4-[[3-(1,3)dioxolan-2-ylbenzoyl]hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-benzaldehyde

3-amino-5-ethyl-4-(3-hydroxymethyl-benzoyl)-6-methyl-1H-pyridin-2-one

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