(E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

• Chemical Name: (E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS No.: 421598-38-1
• Molecular Formula: C₂₀H₂₆N₂O₄
• Molecular Weight: 358.437
• Mol file: 421598-38-1.mol

Synonyms:(E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property of (E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 2 articles about (E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-nitrobenzaldehdye (555-16-8) + (3E)-4-(1R,2S,5R)-(-)-menthyl-1-methyl-1,1-diphenyl-2-aza-1-phosphabuta-1,3-diene (421598-50-7) → (E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (421598-38-1)

Guidance literature:

In chloroform; at 20 ℃; for 2h;

DOI:10.1021/jo016273+

Reference yield:

(E/Z)-(1R,2S,5R)-(-)menthyl 3-azidoacrylate → (E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (421598-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / CH₂Cl₂ / 2 h / 20 °C

2: 67 percent / CHCl₃ / 2 h / 20 °C

In dichloromethane; chloroform;

DOI:10.1021/jo016273+

Reference yield: 52.0%

(E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (421598-38-1) + Diethyl ketomalonate (609-09-6) → 6,6-diethoxycarbonyl-5-(1R,2S,5R)-(-)-menthyloxycarbonyl-2-(4-nitrophenyl)-3,6-dihydro-2H-[1,3]-oxazine

Guidance literature:

In chloroform; for 20h; Heating;

DOI:10.1021/jo016273+

upstream raw materials:

4-nitrobenzaldehdye

(3E)-4-(1R,2S,5R)-(-)-menthyl-1-methyl-1,1-diphenyl-2-aza-1-phosphabuta-1,3-diene