methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

Base Information

• Chemical Name: methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate
• CAS No.: 74614-97-4
• Molecular Formula: C₂₆H₂₇NO₇
• Molecular Weight: 465.503
• Mol file: 74614-97-4.mol

Synonyms:methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

Chemical Property of methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

There total 9 articles about methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

acetic anhydride (108-24-7) + 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,6-dimethyl-1-oxy-pyridine-2-carboxylic acid methyl ester (74614-96-3) → methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate (74614-97-4)

Guidance literature:

at 120 ℃; for 2h;

DOI:10.1021/ja00531a054

Reference yield: 93.0%

acetic anhydride (108-24-7) + methyl 4-<3,4-dimethoxy-2-(9phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide → methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate (74614-97-4)

Guidance literature:

at 120 ℃; for 2h;

DOI:10.1021/ja00366a028

Reference yield:

methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate (74614-94-1) → methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate (74614-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 85percent m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

2: 93 percent / 2 h / 120 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/ja00366a028

upstream raw materials:

acetic anhydride

4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,6-dimethyl-1-oxy-pyridine-2-carboxylic acid methyl ester

methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate

3,4-dimethoxy-(phenylmethoxy)benzaldehyde

Downstream raw materials:

methyl 4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-5-formyl-3,6-dimethyl-2-pyridinecarboxylate

methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-formyl-3-methyl-2-pyridinecarboxylate

methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate