1-[4-(4-Bromo-3-hydroxybenzyl)piperidin-1-yl]ethanone

Base Information

Chemical Name:1-[4-(4-Bromo-3-hydroxybenzyl)piperidin-1-yl]ethanone
CAS No.:1265464-08-1
Molecular Formula:C₁₄H₁₈BrNO₂
Molecular Weight:312.206
Hs Code.:

Synonyms:1-[4-(4-Bromo-3-hydroxybenzyl)piperidin-1-yl]ethanone

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Chemical Property of 1-[4-(4-Bromo-3-hydroxybenzyl)piperidin-1-yl]ethanone

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Technology Process of 1-[4-(4-Bromo-3-hydroxybenzyl)piperidin-1-yl]ethanone

There total 10 articles about 1-[4-(4-Bromo-3-hydroxybenzyl)piperidin-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1265464-14-9
2-bromo-5-(piperidin-4-ylmethyl)phenol

: 108-24-7
acetic anhydride

: 1265464-08-1
1-[4-(4-Bromo-3-hydroxybenzyl)piperidin-1-yl]ethanone

Guidance literature:: In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 1176327-15-3
4-bromo-3-(2-methoxyethoxy)benzoic acid

: 1265464-08-1
1-[4-(4-Bromo-3-hydroxybenzyl)piperidin-1-yl]ethanone

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 3.5 h / 25 °C

1.2: 0.33 h / 20 °C

2.1: triethylamine / trimethylamine hydrochloride / toluene / 2.5 h / 5 °C

3.1: lithium bromide / tetrahydrofuran / 1 h / Reflux

4.1: toluene / 3.5 h / Reflux

5.1: potassium carbonate / isopropyl alcohol / Reflux

6.1: hydrogen / 5% rhodium-on-charcoal / ethyl acetate / 3 h / 15 - 20 °C / 760.05 Torr

7.1: hydrogenchloride / isopropyl alcohol; water / 4.08 h / 55 - 60 °C

8.1: potassium carbonate / 1,4-dioxane; water / 20 °C

9.1: hydrogenchloride / water; methanol / 3.5 h / 20 °C

9.2: pH 8

10.1: 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; triethylamine; lithium bromide; 5% rhodium-on-charcoal; trimethylamine hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

: 1147886-95-0
(4-bromo-3-(2-methoxyethoxy)phenyl)methanol

: 1265464-08-1
1-[4-(4-Bromo-3-hydroxybenzyl)piperidin-1-yl]ethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen bromide / toluene; water / 2 h / 65 - 70 °C

2.1: toluene / 3.5 h / Reflux

3.1: potassium carbonate / isopropyl alcohol / Reflux

4.1: hydrogen / 5% rhodium-on-charcoal / ethyl acetate / 3 h / 15 - 20 °C / 760.05 Torr

5.1: hydrogenchloride / isopropyl alcohol; water / 4.08 h / 55 - 60 °C

6.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice bath

6.2: 20 °C / Cooling with ice bath

7.1: 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; hydrogen bromide; hydrogen; boron tribromide; potassium carbonate; 5% rhodium-on-charcoal; In 1,4-dioxane; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene;