2,2-dimethyl-N-<2-<3-fluoro-5-(4-methoxy-2-pivaloylamino)phenyl-2-pyridyl>phenyl>propanamide

Base Information

Chemical Name:2,2-dimethyl-N-<2-<3-fluoro-5-(4-methoxy-2-pivaloylamino)phenyl-2-pyridyl>phenyl>propanamide
CAS No.:220558-08-7
Molecular Formula:C₂₈H₃₂FN₃O₃
Molecular Weight:477.579
Hs Code.:

Synonyms:2,2-dimethyl-N-<2-<3-fluoro-5-(4-methoxy-2-pivaloylamino)phenyl-2-pyridyl>phenyl>propanamide

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Chemical Property of 2,2-dimethyl-N-<2-<3-fluoro-5-(4-methoxy-2-pivaloylamino)phenyl-2-pyridyl>phenyl>propanamide

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Technology Process of 2,2-dimethyl-N-<2-<3-fluoro-5-(4-methoxy-2-pivaloylamino)phenyl-2-pyridyl>phenyl>propanamide

There total 2 articles about 2,2-dimethyl-N-<2-<3-fluoro-5-(4-methoxy-2-pivaloylamino)phenyl-2-pyridyl>phenyl>propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4-methoxy-2-pivaloylaminophenylboronic acid

: 220557-89-1
2,2-dimethyl-N-<2-(3-fluoro-5-iodo-2-pyridyl)phenyl>propanamide

: 220558-08-7
2,2-dimethyl-N-<2-<3-fluoro-5-(4-methoxy-2-pivaloylamino)phenyl-2-pyridyl>phenyl>propanamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; for 48h; Heating;
DOI:10.3987/com-98-s(h)30

Reference yield:

: 197177-81-4
2,2-dimethyl-N-<2-(3-fluoro-4-iodo-2-pyridyl)phenyl>propanamide

: 220558-08-7
2,2-dimethyl-N-<2-<3-fluoro-5-(4-methoxy-2-pivaloylamino)phenyl-2-pyridyl>phenyl>propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium, diisopropylamine, 2.) H₂O / 1.) THF, -78 deg C, 4 h, 2.) THF, -78 deg C, 2 h

2: 98 percent / K₂CO₃, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene; H₂O / 48 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; water; potassium carbonate; diisopropylamine; In water; toluene;
DOI:10.3987/com-98-s(h)30

Reference yield:

: 220558-08-7
2,2-dimethyl-N-<2-<3-fluoro-5-(4-methoxy-2-pivaloylamino)phenyl-2-pyridyl>phenyl>propanamide

: β-(2-amino-4-hydroxyphenyl)-δ-carboline

Guidance literature:: With ammonium hydroxide; pyridine hydrochloride; Yield given; Multistep reaction; 1.) 215 deg C, 15 min, 2.) ice;
DOI:10.3987/com-98-s(h)30