5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(2-propen-1-yloxy)ethyl]amino}-1-benzofuran-3-carboxamide

Base Information

Chemical Name:5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(2-propen-1-yloxy)ethyl]amino}-1-benzofuran-3-carboxamide
CAS No.:1378428-67-1
Molecular Formula:C₂₅H₂₇FN₂O₅S
Molecular Weight:486.564
Hs Code.:

Synonyms:5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(2-propen-1-yloxy)ethyl]amino}-1-benzofuran-3-carboxamide

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Chemical Property of 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(2-propen-1-yloxy)ethyl]amino}-1-benzofuran-3-carboxamide

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Technology Process of 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(2-propen-1-yloxy)ethyl]amino}-1-benzofuran-3-carboxamide

There total 1 articles about 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(2-propen-1-yloxy)ethyl]amino}-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.6%

: 691852-58-1
nesbuvir

: 35466-83-2
allyl methyl carbonate

: 1378428-67-1
5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(2-propen-1-yloxy)ethyl]amino}-1-benzofuran-3-carboxamide

Guidance literature:: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 1378428-67-1
5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(2-propen-1-yloxy)ethyl]amino}-1-benzofuran-3-carboxamide

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(propyloxy)ethyl]amino}-1-benzofuran-3-carboxamide

: 1378428-68-2
5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)(2-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]oxy}ethyl)amino]-1-benzofuran-3-carboxamide

Guidance literature:: carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride; In tetrahydrofuran; for 6h;

Reference yield:

: 1378428-67-1
5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{(methylsulfonyl)[2-(2-propen-1-yloxy)ethyl]amino}-1-benzofuran-3-carboxamide

: 1378427-23-6
[3-({2-[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]ethyl}oxy)propyl]boronic acid

Guidance literature:: Multi-step reaction with 2 steps

1: carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride / tetrahydrofuran / 6 h

2: hydrogenchloride / water; tetrahydrofuran / 16 h

With hydrogenchloride; carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride; In tetrahydrofuran; water;