2',6'-dihydroxyphenyl imidazol-2-yl ketone

Base Information

• Chemical Name: 2',6'-dihydroxyphenyl imidazol-2-yl ketone
• CAS No.: 81293-95-0
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.185
• Mol file: 81293-95-0.mol

Synonyms:2',6'-dihydroxyphenyl imidazol-2-yl ketone

Chemical Property of 2',6'-dihydroxyphenyl imidazol-2-yl ketone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2',6'-dihydroxyphenyl imidazol-2-yl ketone

There total 4 articles about 2',6'-dihydroxyphenyl imidazol-2-yl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2',6'-dimethoxyphenyl imidazol-2-yl ketone (81293-94-9) → 2',6'-dihydroxyphenyl imidazol-2-yl ketone (81293-95-0)

Guidance literature:

With aluminum tri-bromide; In benzene; for 16h;

DOI:10.1021/jo00132a045

Reference yield:

2,6-dimethoxybenzoyl cyanide (31709-80-5) → 2',6'-dihydroxyphenyl imidazol-2-yl ketone (81293-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / gaseous HCl / CHCl₃ / 72 h / 0 °C

2: ethanol / 3 h / Ambient temperature

3: p-toluenesulfonic acid / 0.5 h / 110 °C

4: 48 percent / AlBr₃ / benzene / 16 h

With hydrogenchloride; aluminum tri-bromide; toluene-4-sulfonic acid; In ethanol; chloroform; benzene;

DOI:10.1021/jo00132a045

Reference yield:

N-(2,2-Diethoxy-ethyl)-2-(2,6-dimethoxy-phenyl)-2-oxo-acetamidine → 2',6'-dihydroxyphenyl imidazol-2-yl ketone (81293-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / 0.5 h / 110 °C

2: 48 percent / AlBr₃ / benzene / 16 h

With aluminum tri-bromide; toluene-4-sulfonic acid; In benzene;

DOI:10.1021/jo00132a045

upstream raw materials:

2',6'-dimethoxyphenyl imidazol-2-yl ketone

2,6-dimethoxybenzoyl cyanide

ethyl 2,6-dimethoxy-α-oxobenzeneacetimidate

Downstream raw materials:

2',6'-dihydroxyphenyl imidazol-2-yl ketone O,O-diacetate