N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

Base Information

Chemical Name:N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide
CAS No.:1236404-83-3
Molecular Formula:C₂₈H₃₅N₃O₄
Molecular Weight:477.604
Hs Code.:

Synonyms:N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

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Chemical Property of N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

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Technology Process of N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

There total 8 articles about N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 89282-70-2
2-methoxyisobutyl amine

: 1236405-00-7
N-(3-formyl-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

: 1236404-83-3
N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

Guidance literature:: 2-methoxyisobutyl amine; N-(3-formyl-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1.5h;

With acetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 4.5h;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1236404-83-3
N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 80 °C

2.2: 0 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C

4.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice

5.1: water; calcium chloride; iron / ethanol / 16 h / 90 °C

6.1: morpholine / butan-1-ol / 24 h / 90 °C

6.2: 4 h / 20 °C

7.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

7.2: 4.5 h / 20 °C

With morpholine; oxalyl dichloride; water; iron; triethylamine; triphenylphosphine; calcium chloride; sodium hydroxide; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; ISOPROPYLAMIDE; toluene; butan-1-ol;

Reference yield:

: 124391-75-9,124506-31-6,15833-61-1
3-tetrahydrofuranmethanol

: 1236404-83-3
N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 80 °C

2.2: 0 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C

4.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice

5.1: water; calcium chloride; iron / ethanol / 16 h / 90 °C

6.1: morpholine / butan-1-ol / 24 h / 90 °C

6.2: 4 h / 20 °C

7.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

7.2: 4.5 h / 20 °C

With morpholine; oxalyl dichloride; water; iron; triethylamine; triphenylphosphine; calcium chloride; sodium hydroxide; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; ISOPROPYLAMIDE; toluene; butan-1-ol;