tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Name:tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1261072-24-5
Molecular Formula:C₄₃H₅₇N₉O₅Si
Molecular Weight:808.068
Hs Code.:

tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Synonyms:tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

There total 13 articles about tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1261071-80-0
(2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1-{[2(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)boronic acid

: 1261072-23-4
tert-butyl (2S)-2-{5-[4-(7-bromopyrido[2,3-b]pyrazin-3-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

: 1261072-24-5
tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 120 ℃; for 0.75h; microwave irradiation; sealed;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1261072-24-5
tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 1.5 h / 0 °C

1.2: 19 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

4.1: TurboGrignard / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 16 h / 20 °C

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.75 h / 120 °C / microwave irradiation; sealed

With sodium hypochlorite; N-Bromosuccinimide; TurboGrignard; sodium hydride; sodium hydrogencarbonate; sodium carbonate; sodium bromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1179149-96-2
tert-butyl (2S)-2-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261072-24-5
tert-butyl (2S)-2-(5-[3-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)pyrido[2,3-b]pyrazin-7-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.75 h / 120 °C / microwave irradiation; sealed

With N-Bromosuccinimide; TurboGrignard; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;