8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol

Base Information

Chemical Name:8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol
CAS No.:860437-87-2
Molecular Formula:C₄₆H₆₈O₄Si₃
Molecular Weight:769.3
Hs Code.:

8-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3,7-bis-(<i>tert</i>-butyl-diphenyl-silanyloxy)-octan-1-ol

Synonyms:8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol

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Chemical Property of 8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol

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Technology Process of 8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol

There total 8 articles about 8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 860438-11-5
8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

: 860437-87-2
8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol

Guidance literature:: 8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 6h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 2h;
DOI:10.1021/ol0511833

Reference yield:

: 4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

: 860437-87-2
8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 86 percent / CSA / CH₂Cl₂; methanol / 6 h / -10 °C

2.1: 82 percent / Dess-Martin reagent; pyridine / CH₂Cl₂ / 4 h / 20 °C

3.1: 72 percent / KHMDS / tetrahydrofuran; toluene / -78 - 20 °C

4.1: 91 percent / H₂ / Pd/C / ethyl acetate / 48 h

5.1: DibalH / CH₂Cl₂; hexane / 6 h / -78 °C

5.2: 89 percent / NaBH₄ / tetrahydrofuran; methanol / 2 h / 0 °C

With pyridine; camphor-10-sulfonic acid; hydrogen; potassium hexamethylsilazane; diisobutylaluminium hydride; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; toluene; 3.1: Julia-Kocienski olefination;
DOI:10.1021/ol0511833

Reference yield:

: 860437-82-7
3-(tert-butyl-diphenyl-silanyloxy)-4-oxo-butyric acid methyl ester

: 860437-87-2
8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 72 percent / KHMDS / tetrahydrofuran; toluene / -78 - 20 °C

2.1: 91 percent / H₂ / Pd/C / ethyl acetate / 48 h

3.1: DibalH / CH₂Cl₂; hexane / 6 h / -78 °C

3.2: 89 percent / NaBH₄ / tetrahydrofuran; methanol / 2 h / 0 °C

With hydrogen; potassium hexamethylsilazane; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; toluene; 1.1: Julia-Kocienski olefination;
DOI:10.1021/ol0511833