methyl 2-(2-fluoro-5-(2-phthalimidoethyl)phenylthio)-2-methylpropionate

Base Information

Chemical Name:methyl 2-(2-fluoro-5-(2-phthalimidoethyl)phenylthio)-2-methylpropionate
CAS No.:358738-28-0
Molecular Formula:C₂₁H₂₀FNO₄S
Molecular Weight:401.459
Hs Code.:

Synonyms:methyl 2-(2-fluoro-5-(2-phthalimidoethyl)phenylthio)-2-methylpropionate

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Chemical Property of methyl 2-(2-fluoro-5-(2-phthalimidoethyl)phenylthio)-2-methylpropionate

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Technology Process of methyl 2-(2-fluoro-5-(2-phthalimidoethyl)phenylthio)-2-methylpropionate

There total 3 articles about methyl 2-(2-fluoro-5-(2-phthalimidoethyl)phenylthio)-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1074-82-4
potassium phtalimide

: 358738-27-9
methyl 2-(5-(2-chloroethyl)-2-fluorophenylthio)-2-methylpropionate

: 358738-28-0
methyl 2-(2-fluoro-5-(2-phthalimidoethyl)phenylthio)-2-methylpropionate

Guidance literature:: With 18-crown-6 ether; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 55 ℃; for 4h;
DOI:10.1081/SCC-100000575

Reference yield:

: 31469-15-5
1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

: 358738-28-0
methyl 2-(2-fluoro-5-(2-phthalimidoethyl)phenylthio)-2-methylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / -78 °C

2: 60 percent / TBAI; 18-crown-6 / dimethylformamide / 4 h / 55 °C

With 18-crown-6 ether; tetra-(n-butyl)ammonium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1081/SCC-100000575

Reference yield:

: 358738-26-8
5-(2-chloroethyl)-3-fluorophenylsulfenyl chloride

: 358738-28-0
methyl 2-(2-fluoro-5-(2-phthalimidoethyl)phenylthio)-2-methylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / -78 °C

2: 60 percent / TBAI; 18-crown-6 / dimethylformamide / 4 h / 55 °C

With 18-crown-6 ether; tetra-(n-butyl)ammonium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1081/SCC-100000575