(S)-4,4-difluoro-2-aminobutyric acid 2,5-difluoro-4-t-butoxycarbonylphenethylamide

Base Information

Chemical Name:(S)-4,4-difluoro-2-aminobutyric acid 2,5-difluoro-4-t-butoxycarbonylphenethylamide
CAS No.:607403-49-6
Molecular Formula:C₁₇H₂₂F₄N₂O₃
Molecular Weight:378.367
Hs Code.:

Synonyms:(S)-4,4-difluoro-2-aminobutyric acid 2,5-difluoro-4-t-butoxycarbonylphenethylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4,4-difluoro-2-aminobutyric acid 2,5-difluoro-4-t-butoxycarbonylphenethylamide

Chemical Property:

Purity/Quality:

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Technology Process of (S)-4,4-difluoro-2-aminobutyric acid 2,5-difluoro-4-t-butoxycarbonylphenethylamide

There total 7 articles about (S)-4,4-difluoro-2-aminobutyric acid 2,5-difluoro-4-t-butoxycarbonylphenethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[2-(2-benzyloxycarbonylamino-4,4-difluoro-butyrylamino)-ethyl]-3,5-difluoro-benzoic acid tert-butyl ester

: 607403-49-6
(S)-4,4-difluoro-2-aminobutyric acid 2,5-difluoro-4-t-butoxycarbonylphenethylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.bmcl.2004.05.093

Reference yield:

: 607403-53-2
2,5-difluoro-4-t-butoxycarbonylphenethylamine

: 607403-49-6
(S)-4,4-difluoro-2-aminobutyric acid 2,5-difluoro-4-t-butoxycarbonylphenethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: EDCI; HOBt; i-Pr₂NEt / CH₂Cl₂

2: H₂ / Pd/C / methanol

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.05.093

Reference yield:

: 3,5-difluorobenzoic acid-tert-butyl ester

: 607403-49-6
(S)-4,4-difluoro-2-aminobutyric acid 2,5-difluoro-4-t-butoxycarbonylphenethylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 77 percent / tetrahydrofuran

2.1: KF; NMM / propan-2-ol / 0 °C

3.1: Ac₂O; NaOAc / 60 °C

4.1: NaBH₄; SiO₂ / propan-2-ol; CHCl₃

5.1: H₂ / Pd/C

6.1: EDCI; HOBt; i-Pr₂NEt / CH₂Cl₂

7.1: H₂ / Pd/C / methanol

With 4-methyl-morpholine; potassium fluoride; sodium tetrahydroborate; hydrogen; sodium acetate; acetic anhydride; silica gel; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; isopropyl alcohol;
DOI:10.1016/j.bmcl.2004.05.093