2-(S)-{[4-(2-diethylcarbamoyl-ethyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-(S)-{[4-(2-diethylcarbamoyl-ethyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1299465-89-6
Molecular Formula:C₃₀H₄₃N₃O₅
Molecular Weight:525.689
Hs Code.:

Synonyms:2-(S)-{[4-(2-diethylcarbamoyl-ethyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2-(S)-{[4-(2-diethylcarbamoyl-ethyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-(S)-{[4-(2-diethylcarbamoyl-ethyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 8 articles about 2-(S)-{[4-(2-diethylcarbamoyl-ethyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1299465-89-6
2-(S)-{[4-(2-diethylcarbamoyl-ethyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 75 °C

2: zinc; acetic acid / methanol / 20 h / 20 °C

3: sodium cyanoborohydride; acetic acid / methanol / 1.5 h / 20 °C

4: palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation

5: sodium hydroxide; water / methanol / 20 h / 20 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

7: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C / 1758.35 Torr

With water; hydrogen; sodium cyanoborohydride; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1299465-88-5
(E)-2-(S)-{[4-(2-diethylcarbamoyl-ethenyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1299465-89-6
2-(S)-{[4-(2-diethylcarbamoyl-ethyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 4h; under 1758.35 Torr;

Reference yield:

: 150-76-5
4-methoxy-phenol

: 1299465-89-6
2-(S)-{[4-(2-diethylcarbamoyl-ethyl)-2-(4-methoxy-phenoxy)-phenylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 75 °C

2: zinc; acetic acid / methanol / 20 h / 20 °C

3: sodium cyanoborohydride; acetic acid / methanol / 1.5 h / 20 °C

4: palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation

5: sodium hydroxide; water / methanol / 20 h / 20 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

7: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C / 1758.35 Torr

With water; hydrogen; sodium cyanoborohydride; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In methanol; N,N-dimethyl-formamide;