4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide

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Chemical Name:4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide
CAS No.:1246433-64-6
Molecular Formula:C₂₇H₂₄FN₇O
Molecular Weight:481.532
Hs Code.:

Synonyms:4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide

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Chemical Property of 4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide

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Technology Process of 4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide

There total 6 articles about 4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6928-85-4
N-amino-N'-methylpiperazine

: 1246433-63-5
4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-benzoic acid

: 1246433-64-6
4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: 4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-benzoic acid; With thionyl chloride; for 12h; Reflux;

N-amino-N'-methylpiperazine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1201786-84-6
3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1246433-64-6
4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

2.2: 1 h

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / sealed tube; Microwave irradiation

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

5.1: thionyl chloride / 12 h / Reflux

5.2: 1 h / 20 °C

With n-butyllithium; thionyl chloride; water; sodium hydride; caesium carbonate; diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1201787-19-0
3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo-[2,3-b:5,4-c']dipyridine

: 1246433-64-6
4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

1.2: 1 h

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / sealed tube; Microwave irradiation

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

4.1: thionyl chloride / 12 h / Reflux

4.2: 1 h / 20 °C

With n-butyllithium; thionyl chloride; water; caesium carbonate; diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;