(S)-(-)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

Base Information

Chemical Name:(S)-(-)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide
CAS No.:223589-13-7
Molecular Formula:C₂₁H₂₉NO₄S
Molecular Weight:391.532
Hs Code.:

Synonyms:(S)-(-)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

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Chemical Property of (S)-(-)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

Chemical Property:

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Technology Process of (S)-(-)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

There total 4 articles about (S)-(-)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 3490-06-0
N-methylhomoveratrylamine

: 223588-90-7
(S)-(-)-3-mesyloxypropyl 4-methoxyphenyl sulfoxide

: 223589-13-7
(S)-(-)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

Guidance literature:: N-methylhomoveratrylamine; With sodium hydride; In tetrahydrofuran; for 2h; Heating;

(S)-(-)-3-mesyloxypropyl 4-methoxyphenyl sulfoxide; In tetrahydrofuran; at 60 - 65 ℃;
DOI:10.1023/A:1018888711071

Reference yield:

: 1879-16-9
1-methoxy-4-methylsulfanyl-benzene

: 223589-13-7
(S)-(-)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / Helminthosporium species NRRL 4671 / Microbiological reaction

2.1: n-butyllithium; diisopropyl amine / tetrahydrofuran; hexane / 1 h / -78 - -30 °C

2.2: 72 percent / hexane; tetrahydrofuran / 1.58 h / -60 - -20 °C

3.1: triethylamine / CH₂Cl₂ / 1 h / 0 °C

4.1: NaH / tetrahydrofuran / 2 h / Heating

4.2: 58 percent / tetrahydrofuran / 60 - 65 °C

With n-butyllithium; Helminthosporium species NRRL 4671; sodium hydride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; 1.1: Oxidation / 2.1: Metallation / 2.2: Addition / 3.1: mesylation / 4.1: Metallation / 4.2: Substitution;
DOI:10.1023/A:1018888711071

Reference yield:

: 3517-99-5,84321-34-6,93381-75-0,93381-76-1
(S)-p-methoxyphenyl methyl sulfoxide

: 223589-13-7
(S)-(-)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropyl amine / tetrahydrofuran; hexane / 1 h / -78 - -30 °C

1.2: 72 percent / hexane; tetrahydrofuran / 1.58 h / -60 - -20 °C

2.1: triethylamine / CH₂Cl₂ / 1 h / 0 °C

3.1: NaH / tetrahydrofuran / 2 h / Heating

3.2: 58 percent / tetrahydrofuran / 60 - 65 °C

With n-butyllithium; sodium hydride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; 1.1: Metallation / 1.2: Addition / 2.1: mesylation / 3.1: Metallation / 3.2: Substitution;
DOI:10.1023/A:1018888711071