6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Base Information

Chemical Name:6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide
CAS No.:1333223-46-3
Molecular Formula:C₃₀H₃₁FN₂O₄S
Molecular Weight:534.652
Hs Code.:

Synonyms:6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Suppliers and Price of 6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

There total 7 articles about 6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1333224-90-0
2-(4-fluorophenyl)-N-methyl-6-(methylsulfonylamino)-5-phenyl-1-benzofuran-3-carboxylic acid

: 2550-36-9
Cyclohexylmethyl bromide

: 1333223-46-3
6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 98-80-6
phenylboronic acid

: 1333223-46-3
6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3: pyridine / dichloromethane / 20 °C

4: water; lithium hydroxide / 1,4-dioxane / 2 h / Reflux

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h

6: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

With pyridine; potassium phosphate tribasic trihydrate; water; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1333223-46-3
6-[(cyclohexylmethyl)(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3: pyridine / dichloromethane / 20 °C

4: water; lithium hydroxide / 1,4-dioxane / 2 h / Reflux

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h

6: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

With pyridine; potassium phosphate tribasic trihydrate; water; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;