3,5-bis-(benzyloxycarbonylaminomethyl)-3',5'-bis-(tert-butoxycarbonylaminomethyl)-4,4'-difluorobiphenyl

Base Information

Chemical Name:3,5-bis-(benzyloxycarbonylaminomethyl)-3',5'-bis-(tert-butoxycarbonylaminomethyl)-4,4'-difluorobiphenyl
CAS No.:1314888-31-7
Molecular Formula:C₄₂H₄₈F₂N₄O₈
Molecular Weight:774.862
Hs Code.:

Synonyms:3,5-bis-(benzyloxycarbonylaminomethyl)-3',5'-bis-(tert-butoxycarbonylaminomethyl)-4,4'-difluorobiphenyl

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Chemical Property of 3,5-bis-(benzyloxycarbonylaminomethyl)-3',5'-bis-(tert-butoxycarbonylaminomethyl)-4,4'-difluorobiphenyl

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Technology Process of 3,5-bis-(benzyloxycarbonylaminomethyl)-3',5'-bis-(tert-butoxycarbonylaminomethyl)-4,4'-difluorobiphenyl

There total 5 articles about 3,5-bis-(benzyloxycarbonylaminomethyl)-3',5'-bis-(tert-butoxycarbonylaminomethyl)-4,4'-difluorobiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1314888-28-2
1,3-bis-(benzyloxycarbonylaminomethyl)-5-bromo-2-fluorobenzene

: 1314888-30-6
1,3-bis-(tert-butoxycarbonylaminomethyl)-2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene

: 1314888-31-7
3,5-bis-(benzyloxycarbonylaminomethyl)-3',5'-bis-(tert-butoxycarbonylaminomethyl)-4,4'-difluorobiphenyl

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; dimethyl sulfoxide; at 60 ℃;
DOI:10.1021/jo200755z

Reference yield:

: 1314888-25-9
5-bromo-1,3-bis-(bromomethyl)-2-fluorobenzene

: 1314888-31-7
3,5-bis-(benzyloxycarbonylaminomethyl)-3',5'-bis-(tert-butoxycarbonylaminomethyl)-4,4'-difluorobiphenyl

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 3 h

1.2: Inert atmosphere; Reflux

1.3: 0.75 h

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; dimethyl sulfoxide / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Gabriel synthesis / 1.2: Gabriel synthesis / 1.3: Gabriel synthesis / 3.1: Suzuki coupling;
DOI:10.1021/jo200755z

Reference yield:

: 1314888-27-1
1,3-bis-(aminomethyl)-5-bromo-2-fluorobenzene

: 1314888-31-7
3,5-bis-(benzyloxycarbonylaminomethyl)-3',5'-bis-(tert-butoxycarbonylaminomethyl)-4,4'-difluorobiphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; dimethyl sulfoxide / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; dimethyl sulfoxide; 2: Suzuki coupling;
DOI:10.1021/jo200755z