5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide

Base Information

Chemical Name:5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide
CAS No.:1020818-04-5
Molecular Formula:C₁₅H₁₈F₂N₄O₄S
Molecular Weight:388.395
Hs Code.:

Synonyms:5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide

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Chemical Property of 5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide

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Technology Process of 5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide

There total 1 articles about 5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1020818-16-9
3-(1,3-dioxolan-2-yl)-2,4-difluoroaniline

: 140174-48-7
4-formyl-N,N-dimethyl-1H-imidazole-1-sulfonamide

: 1020818-04-5
5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide

Guidance literature:: 3-(1,3-dioxolan-2-yl)-2,4-difluoroaniline; 4-formyl-N,N-dimethyl-1H-imidazole-1-sulfonamide; In methanol; at 60 ℃; for 18h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

Reference yield: 84.0%

: 1020818-04-5
5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide

: 75-07-0,9002-91-9
acetaldehyde

: 1020818-05-6
5-[((3-[1,3]dioxolan-2-yl-2,4-difluoro-phenyl)-ethyl-amino)-methyl]-imidazole-1-sulfonic acid dimethylamide

Guidance literature:: 5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide; acetaldehyde; With sodium cyanoborohydride; zinc(II) chloride; In methanol; at 40 ℃; for 18h;

With water; ammonium chloride; In ethyl acetate;

Reference yield:

: 1020818-04-5
5-[(3-[1,3]dioxolan-2-yl-2,4-difluoro-phenylamino)-methyl]-imidazole-1-sulfonic acid dimethylamide

: 1020818-07-8
3-[ethyl-(3H-imidazol-4-ylmethyl)-amino]-2,6-difluoro-benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride; zinc(II) chloride / methanol / 18 h / 40 °C

2: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 24 h / 20 °C

3: hydrogenchloride; water / tetrahydrofuran / 48 h / 20 °C

With hydrogenchloride; water; sodium cyanoborohydride; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol;