11-hydrazino-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline

Base Information

• Chemical Name: 11-hydrazino-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline
• CAS No.: 861219-00-3
• Molecular Formula: C₂₂H₁₅N₇S
• Molecular Weight: 409.474
• Mol file: 861219-00-3.mol

Synonyms:11-hydrazino-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline

Chemical Property of 11-hydrazino-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-hydrazino-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline

There total 4 articles about 11-hydrazino-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

11-chloro-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline (861218-99-7) → 11-hydrazino-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline (861219-00-3)

Guidance literature:

With hydrazine hydrate; In 1,4-dioxane; for 0.5h; Heating;

DOI:10.1080/10426500490494642

Reference yield:

3-cyano-4-(p-tolyl)pyrido[3,2-c]cinnolin-2-thioacetamide (212520-25-7) → 11-hydrazino-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline (861219-00-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / EtONa / ethanol / 1 h / Heating

2: 75 percent / glacial acetic acid / 2 h / Heating

3: 83 percent / POCl₃ / 4 h / Heating

4: 87 percent / hydrazine hydrate / dioxane / 0.5 h / Heating

With sodium ethanolate; hydrazine hydrate; acetic acid; trichlorophosphate; In 1,4-dioxane; ethanol;

DOI:10.1080/10426500490494642

Reference yield:

3-amino-4-(p-tolyl)thieno[3',2':5,6]pyrido[3,2-c]cinnolin-2-carboxamide (212520-46-2) → 11-hydrazino-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline (861219-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / glacial acetic acid / 2 h / Heating

2: 83 percent / POCl₃ / 4 h / Heating

3: 87 percent / hydrazine hydrate / dioxane / 0.5 h / Heating

With hydrazine hydrate; acetic acid; trichlorophosphate; In 1,4-dioxane;

DOI:10.1080/10426500490494642

upstream raw materials:

11-chloro-7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnoline

3-amino-4-(p-tolyl)thieno[3',2':5,6]pyrido[3,2-c]cinnolin-2-carboxamide

3-cyano-4-(p-tolyl)pyrido[3,2-c]cinnolin-2-thioacetamide

7-(p-tolyl)pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnolin-11(10H)-one

Downstream raw materials:

7-(p-tolyl)-1,2,4-triazolo[4''',3''':1'',6'']pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,2-c]cinnolin-3(2H)-thione