2-methyl-2-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-malonic acid dimethyl ester

Base Information

Chemical Name:2-methyl-2-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-malonic acid dimethyl ester
CAS No.:554450-62-3
Molecular Formula:C₂₅H₂₆N₂O₆
Molecular Weight:450.491
Hs Code.:

Synonyms:2-methyl-2-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-malonic acid dimethyl ester

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Chemical Property of 2-methyl-2-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-malonic acid dimethyl ester

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Technology Process of 2-methyl-2-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-malonic acid dimethyl ester

There total 11 articles about 2-methyl-2-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 554450-61-2
2-aminomethyl-2-methyl-malonic acid dimethyl ester

: 362704-62-9
4-[(2-methyl-4-quinolinyl)methoxy]benzoyl chloride

: 554450-62-3
2-methyl-2-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-malonic acid dimethyl ester

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1016/j.bmcl.2006.09.048

Reference yield:

: 609-02-9
methyl-malonic acid dimethylester

: 554450-62-3
2-methyl-2-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaH / dimethylformamide

2: 53 percent / hydrazine / methanol / Heating

3: 94 percent / NaHCO₃ / CH₂Cl₂; H₂O

With sodium hydride; sodium hydrogencarbonate; hydrazine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.09.048

Reference yield:

: 554450-59-8
2-methoxycarbonyl-2-methyl-succinic acid 1-methyl ester

: 554450-62-3
2-methyl-2-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diphenylphosphoryl azide; Et₃N / benzene / Heating

2: 100 percent / H₂ / Pd/C / methanol

3: 94 percent / NaHCO₃ / CH₂Cl₂; H₂O

With diphenylphosphoranyl azide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water; benzene;
DOI:10.1016/j.bmcl.2006.09.048