Technology Process of (2R,3R)-8,8,9,9-Tetrachloro-3-hydroxy-2-methyl-decanoic acid (1S,2R)-2-dimethylamino-1-phenyl-propyl ester
There total 7 articles about (2R,3R)-8,8,9,9-Tetrachloro-3-hydroxy-2-methyl-decanoic acid (1S,2R)-2-dimethylamino-1-phenyl-propyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium tetrachloride;
In
dichloromethane;
at -78 ℃;
for 2h;
Yields of byproduct given;
DOI:10.1021/ja00097a019
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 91 percent / triethylamine / CH2Cl2 / 1 h / 0 °C
2: 1.) LDA / 1.) THF, -78 deg C, 0.5 h, 2.) THF, overnight
3: 60 percent / sulfuryl chloride / benzene; CH2Cl2 / 96 h / Heating
4: 81 percent / 1.5 N aq. NaOH / methanol / 10 h / Ambient temperature
5: 71 percent / Dess-Martin reagent / CH2Cl2 / 4 h
6: 50 percent / TiCl4 / CH2Cl2 / 2 h / -78 °C
With
sodium hydroxide; sulfuryl dichloride; titanium tetrachloride; Dess-Martin periodane; triethylamine; lithium diisopropyl amide;
In
methanol; dichloromethane; benzene;
DOI:10.1021/ja00097a019
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 83 percent / 1,2-diaminoethane, Li, potassium tert-butoxide / 3 h
2: 91 percent / triethylamine / CH2Cl2 / 1 h / 0 °C
3: 1.) LDA / 1.) THF, -78 deg C, 0.5 h, 2.) THF, overnight
4: 60 percent / sulfuryl chloride / benzene; CH2Cl2 / 96 h / Heating
5: 81 percent / 1.5 N aq. NaOH / methanol / 10 h / Ambient temperature
6: 71 percent / Dess-Martin reagent / CH2Cl2 / 4 h
7: 50 percent / TiCl4 / CH2Cl2 / 2 h / -78 °C
With
sodium hydroxide; sulfuryl dichloride; potassium tert-butylate; titanium tetrachloride; lithium; Dess-Martin periodane; ethylenediamine; triethylamine; lithium diisopropyl amide;
In
methanol; dichloromethane; benzene;
DOI:10.1021/ja00097a019
