({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetic acid

Base Information

• Chemical Name: ({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetic acid
• CAS No.: 229630-41-5
• Molecular Formula: C₁₉H₂₁N₃O₅
• Molecular Weight: 371.393
• Mol file: 229630-41-5.mol

Synonyms:({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetic acid

Chemical Property of ({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetic acid

There total 1 articles about ({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetic acid (181519-21-1) → ({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetic acid (229630-41-5)

Guidance literature:

glycine ethyl ester hydrochloride; 3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 20h;

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;

Reference yield:

({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetic acid (229630-41-5) + 3-(3,4-dimethoxy-benzylamino)-propionic acid ethyl ester (67044-05-7) → 3-[N-(3,4-dimethoxybenzyl)-2-{2-[3-methoxy-4-(3-o-tolylureido)phenyl]acetylamino}acetamido]propionic acid ethyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

C24H29N2O4Pol + ({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetic acid (229630-41-5) → C43H48N5O8Pol

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 3h; polystyrene crosslinked with 1percent to 2percent divinylbenzene

upstream raw materials:

glycine ethyl ester hydrochloride

3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetic acid

Downstream raw materials:

3-{[({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetyl]-(3-phenyl-prop-1-yl)-amino}-propionic acid

3-[(4-methoxy-benzyl)-({2-[3-methoxy-4-(3-o-tolylureido)phenyl]-acetylamino}-acetyl)-amino-]-propionic acid

3-{(4-pyridylmethyl)-[({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-amino)-acetyl]-amino}-propionic acid

3-[cyclohexymethyl-({2-[3-methoxy-4-(3-o-tolylureido)phenyl]-acetylamino}-acetyl)-amino]-propionic acid