4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1346175-23-2
Molecular Formula:C₃₀H₂₃FN₄O₃S
Molecular Weight:538.602
Hs Code.:

Synonyms:4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

There total 7 articles about 4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1401083-50-8
C₂₉H₄₁FN₂OSn

: 744209-63-0
1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine

: 1346175-23-2
4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With palladium diacetate; XPhos; In N,N-dimethyl-formamide; at 76 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; Time;
DOI:10.1021/jm300852w

Reference yield:

: 889939-25-7
1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine

: 1213269-68-1
4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazole

: 1346175-23-2
4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With tributyltin chloride; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h; Inert atmosphere;

1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine; With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 101 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1016/j.tet.2011.09.053

Reference yield:

: 1213269-68-1
4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazole

: 744209-63-0
1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine

: 1346175-23-2
4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With tributyltin chloride; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h; Inert atmosphere;

1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine; With palladium diacetate; XPhos; In 1,4-dioxane; at 101 ℃; for 0.0833333h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.tet.2011.09.053