N-p-hydroxyphenyl-3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxamide

Base Information

• Chemical Name: N-p-hydroxyphenyl-3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxamide
• CAS No.: 163188-34-9
• Molecular Formula: C₁₇H₂₁NO₃
• Molecular Weight: 287.359
• Mol file: 163188-34-9.mol

Synonyms:N-p-hydroxyphenyl-3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxamide

Chemical Property of N-p-hydroxyphenyl-3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-p-hydroxyphenyl-3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxamide

There total 3 articles about N-p-hydroxyphenyl-3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-amino-phenol (123-30-8) + 3,6,6-Trimethyl-7-oxo-cyclohept-3-enecarbonyl chloride → N-p-hydroxyphenyl-3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxamide (163188-34-9)

Guidance literature:

With sodium acetate; In acetic acid; for 1.5h; Ambient temperature;

DOI:10.1271/bbb.60.1421

Reference yield:

2,2,5-trimethylcyclohept-4-en-1-one (19822-67-4) → N-p-hydroxyphenyl-3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxamide (163188-34-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 86.4 percent / lithium diisopropylamide / diethyl ether; hexane

2: 82 percent / thionyl chloride / hexamethylphosphoric acid triamide / 0.67 h / -5 °C

3: 77 percent / aq. sodium acetate / acetic acid / 1.5 h / Ambient temperature

With thionyl chloride; sodium acetate; lithium diisopropyl amide; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; acetic acid;

DOI:10.1271/bbb.60.1421

Reference yield:

3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxylic acid (163188-36-1) → N-p-hydroxyphenyl-3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxamide (163188-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / thionyl chloride / hexamethylphosphoric acid triamide / 0.67 h / -5 °C

2: 77 percent / aq. sodium acetate / acetic acid / 1.5 h / Ambient temperature

With thionyl chloride; sodium acetate; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetic acid;

DOI:10.1271/bbb.60.1421

upstream raw materials:

4-amino-phenol

2,2,5-trimethylcyclohept-4-en-1-one

3,3,6-trimethyl-5-cyclohepten-2-one-1-carboxylic acid