Technology Process of p-tolyl 2,3-di-O-levulinoyl-4,6-O-benzylidene-β-D-galactopyranosyl-(1→3)-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside
There total 11 articles about p-tolyl 2,3-di-O-levulinoyl-4,6-O-benzylidene-β-D-galactopyranosyl-(1→3)-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
p-tolyl 4,6-O-benzylidene-2,3-di-O-levulinoyl-1-thio-β-D-galactopyranoside;
With
silver trifluoromethanesulfonate;
In
diethyl ether; dichloromethane;
at -78 ℃;
for 0.0833333h;
Inert atmosphere;
Molecular sieve;
With
para-thiocresol;
In
diethyl ether; dichloromethane;
at -78 ℃;
for 0.0833333h;
Inert atmosphere;
p-methylphenyl 2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside;
With
2,4,6-tri-tert-butylpyrimidine;
In
diethyl ether; dichloromethane;
at -78 - 0 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/anie.201205601
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 20 h / 20 °C / Inert atmosphere
2.1: sodium methylate / dichloromethane; methanol / 20 °C / Inert atmosphere
2.2: pH 7 / Inert atmosphere
3.1: camphor-10-sulfonic acid / acetonitrile / 20 °C / Inert atmosphere
4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere
5.1: dmap / dichloromethane / 50 °C / Inert atmosphere
6.1: acetic acid; hydrazine hydrate / dichloromethane; methanol / 20 °C / Inert atmosphere
7.1: silver trifluoromethanesulfonate / dichloromethane; diethyl ether / 0.08 h / -78 °C / Inert atmosphere; Molecular sieve
7.2: 0.08 h / -78 °C / Inert atmosphere
7.3: 2 h / -78 - 0 °C / Inert atmosphere
With
dmap; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; sodium methylate; silver trifluoromethanesulfonate; hydrazine hydrate; acetic acid; dicyclohexyl-carbodiimide;
In
methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1002/anie.201205601
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 20 h / 20 °C / Inert atmosphere
2.1: sodium methylate / dichloromethane; methanol / 20 °C / Inert atmosphere
2.2: pH 7 / Inert atmosphere
3.1: camphor-10-sulfonic acid / acetonitrile / 20 °C / Inert atmosphere
4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere
5.1: dmap / dichloromethane / 50 °C / Inert atmosphere
6.1: acetic acid; hydrazine hydrate / dichloromethane; methanol / 20 °C / Inert atmosphere
7.1: silver trifluoromethanesulfonate / dichloromethane; diethyl ether / 0.08 h / -78 °C / Inert atmosphere; Molecular sieve
7.2: 0.08 h / -78 °C / Inert atmosphere
7.3: 2 h / -78 - 0 °C / Inert atmosphere
With
dmap; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; sodium methylate; silver trifluoromethanesulfonate; hydrazine hydrate; acetic acid; dicyclohexyl-carbodiimide;
In
methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1002/anie.201205601
