ethyl 3-(2-amino-5-methoxybenzoyl)-1-cyclohexanecarbonyl-Δ²-pyrazoline-5-carboxylate

Base Information

• Chemical Name: ethyl 3-(2-amino-5-methoxybenzoyl)-1-cyclohexanecarbonyl-Δ²-pyrazoline-5-carboxylate
• CAS No.: 710301-07-8
• Molecular Formula: C₂₁H₂₇N₃O₅
• Molecular Weight: 401.462

Synonyms:ethyl 3-(2-amino-5-methoxybenzoyl)-1-cyclohexanecarbonyl-Δ²-pyrazoline-5-carboxylate

Chemical Property of ethyl 3-(2-amino-5-methoxybenzoyl)-1-cyclohexanecarbonyl-Δ²-pyrazoline-5-carboxylate

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Technology Process of ethyl 3-(2-amino-5-methoxybenzoyl)-1-cyclohexanecarbonyl-Δ²-pyrazoline-5-carboxylate

There total 5 articles about ethyl 3-(2-amino-5-methoxybenzoyl)-1-cyclohexanecarbonyl-Δ²-pyrazoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl 1-cyclohexanecarbonyl-3-(5-methoxy-2-nitrobenzoyl)-Δ2-pyrazoline-5-carboxylate (710300-42-8) → ethyl 3-(2-amino-5-methoxybenzoyl)-1-cyclohexanecarbonyl-Δ2-pyrazoline-5-carboxylate (710301-07-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1.5h; under 3620.13 Torr;

DOI:10.1016/j.tet.2004.03.013

Reference yield:

5-methoxy-2-nitrobenzoyl chloride (63932-00-3) → ethyl 3-(2-amino-5-methoxybenzoyl)-1-cyclohexanecarbonyl-Δ2-pyrazoline-5-carboxylate (710301-07-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / diethyl ether / 3 h

2: 80 percent / 16 h

3: 98 percent / triethylamine / CH₂Cl₂ / 3 h / 20 °C

4: 82 percent / H₂ / Pd/C / methanol / 1.5 h / 3620.13 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2004.03.013

Reference yield:

5-methoxy-2-nitrophenyl vinyl ketone (145474-19-7) → ethyl 3-(2-amino-5-methoxybenzoyl)-1-cyclohexanecarbonyl-Δ2-pyrazoline-5-carboxylate (710301-07-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / pyridine / acetonitrile / 10 h

2: 98 percent / triethylamine / CH₂Cl₂ / 3 h / 20 °C

3: 82 percent / H₂ / Pd/C / methanol / 1.5 h / 3620.13 Torr

With pyridine; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2004.03.013

upstream raw materials:

ethyl 1-cyclohexanecarbonyl-3-(5-methoxy-2-nitrobenzoyl)-Δ²-pyrazoline-5-carboxylate

5-methoxy-2-nitrobenzoyl chloride

5-methoxy-2-nitrophenyl vinyl ketone

5-methoxy-2-nitrodiazoacetophenone

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