9-chloro-1-<(dimethylamino)methyl>4,5-dihydro-7-phenyl-s-triazolo<4,3-a><1,5>benzodiazocine

Base Information

Chemical Name:9-chloro-1-<(dimethylamino)methyl>4,5-dihydro-7-phenyl-s-triazolo<4,3-a><1,5>benzodiazocine
CAS No.:72882-77-0
Molecular Formula:C₂₀H₂₀ClN₅
Molecular Weight:365.865
Hs Code.:

Synonyms:9-chloro-1-<(dimethylamino)methyl>4,5-dihydro-7-phenyl-s-triazolo<4,3-a><1,5>benzodiazocine

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Chemical Property of 9-chloro-1-<(dimethylamino)methyl>4,5-dihydro-7-phenyl-s-triazolo<4,3-a><1,5>benzodiazocine

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Technology Process of 9-chloro-1-<(dimethylamino)methyl>4,5-dihydro-7-phenyl-s-triazolo<4,3-a><1,5>benzodiazocine

There total 4 articles about 9-chloro-1-<(dimethylamino)methyl>4,5-dihydro-7-phenyl-s-triazolo<4,3-a><1,5>benzodiazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 72874-33-0
N-<2-<4-(2-benzoyl-4-chlorophenyl)-5-<(dimethylamino)methyl>-4H-1,2,4-triazol-3-yl>ethyl>phthalimide

: 72882-77-0
9-chloro-1-<(dimethylamino)methyl>4,5-dihydro-7-phenyl-s-triazolo<4,3-a><1,5>benzodiazocine

Guidance literature:: With hydrazine hydrate; In ethanol; at 70 ℃; for 1.5h;
DOI:10.1021/jm00178a009

Reference yield:

: 60639-82-9
8-chloro-6-phenyl-1-(2-phthalimidoethyl)-4H-s-triazolo<4,3-a><1,4>benzodiazepine

: 72882-77-0
9-chloro-1-<(dimethylamino)methyl>4,5-dihydro-7-phenyl-s-triazolo<4,3-a><1,5>benzodiazocine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 88percent aq. HCO₂H / 1 h / 100 °C

2: 41 percent / 1.) H₂NNH₂*H₂O / ethanol / 1.5 h / 70 °C

With formic acid; hydrazine hydrate; In ethanol;
DOI:10.1021/jm00178a009

Reference yield:

: 18091-89-9,112393-62-1
7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine

: 72882-77-0
9-chloro-1-<(dimethylamino)methyl>4,5-dihydro-7-phenyl-s-triazolo<4,3-a><1,5>benzodiazocine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) carbonyldiimidazole / 1.) THF, RT, 72 min, 2.) THF, RT, 18 h

2: acetic acid / 0.7 h / 117 °C

3: 82 percent / 88percent aq. HCO₂H / 1 h / 100 °C

4: 41 percent / 1.) H₂NNH₂*H₂O / ethanol / 1.5 h / 70 °C

With formic acid; hydrazine hydrate; 1,1'-carbonyldiimidazole; In ethanol; acetic acid;
DOI:10.1021/jm00178a009