1-benzyl-4-(2,2'-bipyridin-5-yl)-1H-1,2,3-triazole

Base Information

Chemical Name:1-benzyl-4-(2,2'-bipyridin-5-yl)-1H-1,2,3-triazole
CAS No.:1245740-46-8
Molecular Formula:C₁₉H₁₅N₅
Molecular Weight:313.362
Hs Code.:

Synonyms:1-benzyl-4-(2,2'-bipyridin-5-yl)-1H-1,2,3-triazole

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Chemical Property of 1-benzyl-4-(2,2'-bipyridin-5-yl)-1H-1,2,3-triazole

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Technology Process of 1-benzyl-4-(2,2'-bipyridin-5-yl)-1H-1,2,3-triazole

There total 7 articles about 1-benzyl-4-(2,2'-bipyridin-5-yl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 622-79-7
benzyl azide

: 162318-34-5
5-ethynyl-2,2'-bipyridine

: 1245740-46-8
1-benzyl-4-(2,2'-bipyridin-5-yl)-1H-1,2,3-triazole

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 3h;
DOI:10.1016/j.ica.2010.04.019

Reference yield:

: 109-04-6
2-bromo-pyridine

: 1245740-46-8
1-benzyl-4-(2,2'-bipyridin-5-yl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 18 h / Inert atmosphere; Reflux

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 24 h / Inert atmosphere; Reflux

3.1: pyridine; sodium azide; potassium carbonate; copper(II) sulfate; ascorbic acid / methanol; water

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium azide; potassium carbonate; copper(II) sulfate; triethylamine; ascorbic acid; In tetrahydrofuran; methanol; hexane; water; 1.1: Negishi coupling / 1.2: Negishi coupling / 1.3: Negishi coupling / 2.1: Sonogashira coupling;
DOI:10.1055/s-0030-1260256

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1245740-46-8
1-benzyl-4-(2,2'-bipyridin-5-yl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 24 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

2.3: 18 h / Inert atmosphere; Reflux

3.1: pyridine; sodium azide; potassium carbonate; copper(II) sulfate; ascorbic acid / methanol; water

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium azide; potassium carbonate; copper(II) sulfate; triethylamine; ascorbic acid; In tetrahydrofuran; methanol; hexane; water; 1.1: Sonogashira coupling / 2.1: Negishi coupling / 2.2: Negishi coupling / 2.3: Negishi coupling;
DOI:10.1055/s-0030-1260256