6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Base Information

Chemical Name:6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile
CAS No.:1315465-32-7
Molecular Formula:C₁₆H₁₃F₃N₆O
Molecular Weight:362.314
Hs Code.:

Synonyms:6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

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Chemical Property of 6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

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Technology Process of 6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

There total 12 articles about 6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50824-04-9
4-bromo-2-(trifluoromethyl)phenol

: 1315465-32-7
6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / acetonitrile / Reflux

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3: potassium carbonate; sodium azide / N,N-dimethyl-formamide / 20 - 60 °C

4: triphenylphosphine / tetrahydrofuran / 1 h

5: dichloromethane / 2 h

6: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

7: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

8: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 1 h / 20 °C

9: trifluoroacetic acid

With hydrogenchloride; potassium phosphate; sodium azide; potassium acetate; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 944388-71-0
4-amino-6-chloro-3-nitropyridine-2-carbonitrile

: 1315465-32-7
6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 5 h / 80 °C

2: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C

3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

4: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 1 h / 20 °C

5: trifluoroacetic acid

With hydrogenchloride; potassium phosphate; tin(II) chloride dihdyrate; potassium carbonate; trifluoroacetic acid; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; ethanol; water; acetonitrile;

Reference yield:

: 1104382-36-6
2-(4-bromo-2-(trifluoromethyl)phenoxy)-ethanol

: 1315465-32-7
6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: potassium carbonate; sodium azide / N,N-dimethyl-formamide / 20 - 60 °C

3: triphenylphosphine / tetrahydrofuran / 1 h

4: dichloromethane / 2 h

5: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

6: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

7: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 1 h / 20 °C

8: trifluoroacetic acid

With hydrogenchloride; potassium phosphate; sodium azide; potassium acetate; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;