7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Base Information

Chemical Name:7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide
CAS No.:856698-49-2
Molecular Formula:C₂₁H₂₂FN₃O₃
Molecular Weight:383.422
Hs Code.:

Synonyms:7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

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Chemical Property of 7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

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Technology Process of 7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

There total 3 articles about 7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide fumaric acid salt

: 856698-49-2
7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 46.0%

: 498529-52-5
7-dimethylaminomethyl-8-hydroxy-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

: 237436-54-3
1-[1-(4-fluorophenyl)vinyl]pyrrolidine

: 856698-49-2
7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1016/j.tetasy.2008.05.013

Reference yield:

: 7-dimethylaminomethyl-8-hydroxy-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide iodide salt

: 237436-54-3
1-[1-(4-fluorophenyl)vinyl]pyrrolidine

: 856698-49-2
7-[3-(4-fluorophenyl)-3-oxo-propyl]-8-hydroxy-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Guidance literature:: 7-dimethylaminomethyl-8-hydroxy-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide iodide salt; 1-[1-(4-fluorophenyl)vinyl]pyrrolidine; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

With hydrogenchloride; In dichloromethane; water; N,N-dimethyl-formamide; at 0 ℃; pH=7; Product distribution / selectivity;